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JR-AB2-011 B
CAS No. 2411853-34-2
JR-AB2-011 B( —— )
Catalog No. M32976 CAS No. 2411853-34-2
JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. It inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM) and exhibits cytotoxicity in glioblastoma .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 132 | In Stock |
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| 5MG | 202 | In Stock |
|
| 10MG | 345 | In Stock |
|
| 25MG | 610 | In Stock |
|
| 50MG | 915 | In Stock |
|
| 100MG | 1197 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameJR-AB2-011 B
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NoteResearch use only, not for human use.
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Brief DescriptionJR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. It inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM) and exhibits cytotoxicity in glioblastoma .
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DescriptionJR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM). JR-AB2-011 has anti-glioblastoma multiforme (GBM) properties.
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In VitroApoptosis Analysis Cell Line:U87 GBM cells; LN229 GBM cells Concentration:1 μM Incubation Time:24 hours Result:Had good anti-GBM properties and blocked mTORC2 signaling and Rictor association with mTOR. Cell Cytotoxicity Assay Cell Line:Normal mature human neurons Concentration:0.5, 1, 2 μM Incubation Time:48 hours Result:Displayed the least toxicity to normal neurons with no significant cytotoxic effects for concentrations up to 10 mM.
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In VivoAnimal Model:LN229 cells in female C.B.-17-scid (Taconic) mice Dosage:4 mg/kg; 20 mg/kg Administration:Daily i.p.; 10 days Result:Either dosing regimen displayed marked inhibition of tumor growth rate as compared to mice receiving vehicle alone.
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptormTOR
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Research Area——
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Indication——
Chemical Information
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CAS Number2411853-34-2
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Formula Weight398.28
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Molecular FormulaC17H14Cl2FN3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (156.92 mM; Ultrasonic )
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SMILESCC1CN(C(=O)Nc2ccc(Cl)c(Cl)c2)\C(S1)=N\c1ccc(F)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Benavides-Serrato A, et al. Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxicin glioblastoma. PLoS One. 2019 Feb 6;14(2):e0212160.?
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